Red Cell Magnesium and Glutathione Peroxidase in Infertile Women – Effects of Oral Supplementation with Magnesium and Selenium

McLaren Howard J, Davies S, Hunnisett A G Mag. Res. 1994;7:49-57 Six women with a history of unexplained infertility or early miscarriage and who had failed to normalise their red cell magnesium (RBC-Mg) levels after four months of oral magnesium supplementation (600mg/day) were investigated for red cell glutathione peroxidase activity (RBC-GSH-Px) and were compared with six age-matched women with a history of unexplained infertility of miscarriage who did normalise their RBC-Mg levels on magnesium supplementation. The six non-normalisers had significantly lower (P<0.0001) RBC-GSH-Px levels than the six normalisers. After a further two months of 200�g daily oral selenium as selenomethionine and oral magnesium supplements, all six women normalised their RBC-Mg (P<0.0001) and RBC-GSH-Px (P<0.0001) levels. All 12 previously infertile women have produced normal healthy babies all conceiving within eight months of normalising their RBC-Mg levels. The possible relevance of these findings to the medical treatment of infertility is discussed.