This test assesses metabolism of the essential amino acid methionine (Met). Methionine is paramount in two metabolic processes; (1) transmethylation that is critical for the methylation of hundreds of important molecules such as DNA, RNA, proteins, neurotransmitters and membrane phosphatidylcholine, and (2) transsulfurration that leads to the biosynthesis of cysteine and hence glutathione , both of which have many important protective / detoxification functions. Aberrant Met metabolism can be caused by nutritional deficiencies, exposures to environmental toxicants and/or genetic polymorphisms and can have significant adverse health consequences. Identification of such abnormalities can guide appropriate nutritional intervention towards normalization of methionine metabolism and decreased risk and incidence of adverse health effects. The amino acids and intermediary amino acid metabolites were measured by liquid chromatography - mass spectrometry. Reference values are age and sex specific. If patient values deviate from normal, comprehensive descriptive paragraphs will be presented as part of the test report.
Patients need to attend Biolab for this test as the blood samples have to be centrifuged and the samples immediately frozen. Overnight fast and avoid methionine, cysteine, and SAMe supplements for 48 hours prior to the test.
Sample Collection Instructions:
Use Doctor's Data kit (transfer EDTa blood to two supplied tubes & mix).Samples should be separated promptly (within 15 minutes) and frozen within 45 minutes.