Zonulin - Serum


This test measures a zonulin family protein (ZFP), identified as properdin. High serum levels of ZFP (antigen) are correlated with abnormal results of the Lactulose Mannitol test; the long-accepted standard for intestinal permeability. Elevated levels of ZFP have been associated with metabolic syndrome, obesity, and several autoimmune, inflammatory and neoplastic diseases. Such diseases include Celiac disease, type I diabetes, juvenile nonalcoholic fatty liver disease, and evidence is accumulating for multiple sclerosis, rheumatoid arthritis, asthma and inflammatory bowel disease. Elevated serum levels of ZFP and increased permeability are commonly observed in patients at risk of developing Crohn’s disease and type 1 diabetes patients, prior to the onset of symptoms.

Also see Biolab's Gut Permeability Profile.

Patient Instructions:

Patient must attend Biolab for this blood test.

Sample Report:

rep_zonulin_serum.pdf (Click to Download)

Sample Requirements:

Gold top (SST) clotted blood

Postal Samples Acceptable:


For further details please contact the laboratory at: lab@xxxxbiolab.co.uk