Volatile Organic Compounds in Blood
Introduction. Petroleum-related chemicals such as benzene are commonly found in the general environment. They are fat soluble and enter the body by inhalation, skin absorption and orally. It is almost impossible to avoid exposure to a range of these chemicals. For this reason, we quote the population average level when reporting the findings.
Many of these compounds are hepatotoxic and some are carcinogenic. There can be synergistic effects on liver function and it is reasonable to suppose that carcinogenic risk is also total dose-related for some groups of chemicals.
VOCs are measured to assess exposure from the patient’s general environment, specific work-place exposure and the use of volatile chemicals in the home or hobby activities (DIY, paints, glues etc).
Patients with other stresses on their detoxification pathways from drugs in use, nutrient deficiencies, or underlying diseases may accumulate increased levels of VOCs from their environment. Patients with poor antioxidant status and/or other risk factors for malignancy may be more sensitive to these compounds. Some people develop chemical sensitivity to these compounds or the chemical groups to which they belong.
Sample required. A whole blood sample is taken into heparin. The tube is sealed to prevent loss of volatile components. The use of the Vacutainer (or a similar system) is ideal. Samples may be stored at around 50C but they should not be frozen.
Links to other Biolab tests:
Vitamins and related functional tests
Trace and toxic elements and related functional tests
Other Biolab tests and challenge tests